The Construction of Analogy-Based Research Programs

Rebecca Mertens

doi:10.14361/9783839444429

Zusammenfassung

When the German chemist Emil Fischer presented his lock-and-key hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity.Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling.

Schlagworte

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Bibliographische Angaben

Copyrightjahr: 2019
ISBN-Print: 978-3-8376-4442-5
ISBN-Online: 978-3-8394-4442-9
Verlag: transcript, Bielefeld
Reihe: Science Studies
Band: 0
Sprache: Englisch
Seiten: 224
Produkttyp: Monographie

Inhaltsverzeichnis

KapitelSeiten

FrontmatterSeiten 1 - 4 Download Kapitel (PDF)
Table of contentsSeiten 5 - 6 Download Kapitel (PDF)
Preface Kein Zugriff Seiten 7 - 8
1 The lock-and-key analogy and its influence on 20<sup>th</sup> century biochemistry Kein Zugriff Seiten 9 - 38
2 The lock-and-key analogy in Emil Fischer''s program on sugar fermentation, 1890-1907 Kein Zugriff Seiten 39 - 76
3 The making of the lock-and-key model of the antibody-antigen relationship, 1886-1930 Kein Zugriff Seiten 77 - 132
4 Lock-and-key foundations for molecular biology: Linus Pauling and the Caltech group, 1930-1960 Kein Zugriff Seiten 133 - 172
5 Lock-and-key-based modeling and its influence on the development of biochemical research programs Kein Zugriff Seiten 173 - 198
6 Concluding remarks on the construction of analogy-based research programs Kein Zugriff Seiten 199 - 204
Literature Kein Zugriff Seiten 205 - 224