Warum ist die Früherkennung von Alzheimer wichtig?

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Cover of book: Disease Interception als Chance und Herausforderung
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Disease Interception als Chance und Herausforderung

Eine interdisziplinäre Analyse

Authors:
Series
Bochumer Schriften zum Sozial- und Gesundheitsrecht
Volume
26
Publisher
Nomos, Baden-Baden
Copyright year
2024
ISBN-Print
978-3-7560-1633-4
ISBN-Online
978-3-7489-4092-0

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Open Access Full access

Warum ist die Früherkennung von Alzheimer wichtig?

Authors:
ISBN-Print
978-3-7560-1633-4
ISBN-Online
978-3-7489-4092-0
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Bibliography

  1. Literaturverzeichnis Open Google Scholar doi.org/10.5771/9783748940920-69
  2. Albert, M. S. / DeKosky, S. T. / Dickson, D. / Dubois, B. / Feldman, H. H. / Fox, N. C. / Gamst, A. / Holtzman, D. M. / Jagust, W. J. / Petersen, R. C. / Snyder, P. J. / Carrillo, M. C. / Thies, B. / Phelps, C. H.: The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease, Alzheimers Dement 2011;7(3):270–279 (https://doi.org/10.1016/j.jalz.2011.03.008). Open Google Scholar doi.org/10.5771/9783748940920-69
  3. Arndt, J. W. / Qian, F. / Smith, B. A. / Quan, C. / Kilambi, K. P. / Bush, M. W. / Walz, T. / Pepinsky, R. B. / Bussière, T. / Hamann, S. / Cameron, T. O. / Weinreb, P. H.: Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β, Sci Rep 2018;8(1):6412 (https://doi.org/10.1038/s41598-018-24501-0). Open Google Scholar doi.org/10.5771/9783748940920-69
  4. Bateman, R. J. / Xiong, C. / Benzinger, T. L. S. / Fagan, A. M. / Goate, A. / Fox, N. C. / Marcus, D. S. / Cairns, N. J. / Xie, X. / Blazey, T. M. / Holtzman, D. M. / Santacruz, A. / Buckles, V. / Oliver, A. / Moulder, K. / Aisen, P. S. / Ghetti, B. / Klunk, W. E. / McDade, E. / Martins, R. N. / Masters, C. L. / Mayeux, R. / Ringman, J. M. / Rossor, M. N. / Schofield, P. R. / Sperling, R. A. / Salloway, S. / Morris, J. C.: Clinical and biomarker changes in dominantly inherited Alzheimer's disease, N Engl J Med 2012;367(9):795–804 (https://doi.org/10.1056/NEJMoa1202753). Open Google Scholar doi.org/10.5771/9783748940920-69
  5. Beyer, L. / Günther, R. / Koch, J. C. / Klebe, S. / Hagenacker, T. / Lingor, P. / Biesalski, A.-S. / Hermann, A. / Nabers, A. / Gold, R. / Tönges, L. / Gerwert, K: TDP-43 as structure-based biomarker in amyotrophic lateral sclerosis, Ann Clin Transl Neurol 2021;8(1):271–277 (https://doi.org/10.1002/acn3.51256). Open Google Scholar doi.org/10.5771/9783748940920-69
  6. Beyer, L. / Stocker, H. / Rujescu, D. / Holleczek, B. / Stockmann, J. / Nabers, A. / Brenner, H. / Gerwert, K.: Amyloid-beta misfolding and GFAP predict risk of clinical Alzheimer's disease diagnosis within 17 years, Alzheimers Dement 2022 (https://doi.org/10.1002/alz.12745). Open Google Scholar doi.org/10.5771/9783748940920-69
  7. Beyreuther, K. / Masters, C. L.: Amyloid precursor protein (APP) and beta A4 amyloid in the etiology of Alzheimer's disease: precursor-product relationships in the derangement of neuronal function, Brain Pathol 1991;1(4):241–251 (https://doi.org/10.1111/j.1750-3639.1991.tb00667.x). Open Google Scholar doi.org/10.5771/9783748940920-69
  8. Braak, H. / Braak, E.: Neuropathological stageing of Alzheimer-related changes, Acta Neuropathol 1991;82(4):239–259 (https://doi.org/10.1007/BF00308809). Open Google Scholar doi.org/10.5771/9783748940920-69
  9. Budd Haeberlein, S. / Aisen, P. S. / Barkhof, F. / Chalkias, S. / Chen, T. / Cohen, S. / Dent, G. / Hansson, O. / Harrison, K. / Hehn, C. von / Iwatsubo, T. / Mallinckrodt, C. / Mummery, C. J. / Muralidharan, K. K. / Nestorov, I. / Nisenbaum, L. / Rajagovindan, R. / Skordos, L. / Tian, Y. / van Dyck, C. H. / Vellas, B. / Wu, S. / Zhu, Y. / Sandrock, A.: Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease, J Prev Alzheimers Dis 2022;9(2):197–210 (https://doi.org/10.14283/jpad.2022.30). Open Google Scholar doi.org/10.5771/9783748940920-69
  10. Buchhave, P. / Minthon, L. / Zetterberg, H. / Wallin, A. K / Blennow, K. / Hansson, O.: Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia, Arch Gen Psychiatry 2012;69(1):98–106 (https://doi.org/10.1001/archgenpsychiatry.2011.155). Open Google Scholar doi.org/10.5771/9783748940920-69
  11. Chang, R. C.-C. / Ho, Y.-S. / Wong, S. / Gentleman, S. M. / Ng, H.-K.: Neuropathology of cigarette smoking, Acta Neuropathol 2014;127(1):53–69 (https://doi.org/10.1007/s00401-013-1210-x). Open Google Scholar doi.org/10.5771/9783748940920-69
  12. Chien, D.T. / Szardenings, A. K. / Bahri, S. / Walsh, J. C. / Mu, F. / Xia, C. / Shankle, W. R. / Lerner, A. J. / Su, M.-Y. / Elizarov, A. / Kolb, H.C.: Early clinical PET imaging results with the novel PHF-tau radioligand F18-T808, J Alzheimers Dis 2014;38(1):171–184 (https://doi.org/10.3233/JAD-130098). Open Google Scholar doi.org/10.5771/9783748940920-69
  13. Das, S. R. / Xie, L. / Wisse, L. E. M. / Ittyerah, R. / Tustison, N. J. / Dickerson, B. C. / Yushkevich, P. A. / Wolk, D. A.: Longitudinal and cross-sectional structural magnetic resonance imaging correlates of AV-1451 uptake, Neurobiol Aging 2018;66:49–58 (https://doi.org/10.1016/j.neurobiolaging.2018.01.024). Open Google Scholar doi.org/10.5771/9783748940920-69
  14. Dubois, B. / Feldman, H. H. / Jacova, C. / Hampel, H. / Molinuevo, J. L. / Blennow, K. / DeKosky, S. T. / Gauthier, S. / Selkoe, D. / Bateman, R. / Cappa, S. / Crutch, S. / Engelborghs, S. / Frisoni, G. B. / Fox, N. C. / Galasko, D. / Habert, M.-O. / Jicha, G. A. / Nordberg, A. / Pasquier, F. / Rabinovici, G. / Robert, P. / Rowe, C. / Salloway, S. / Sarazin, M. / Epelbaum, S. / Souza L.C. de / Vellas, B. / Visser, P.J. / Schneider, L. / Stern, Y. / Scheltens, P. / Cummings, J.L.: Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria, Lancet Neurol 2014;13(6):614–629 (https://doi.org/10.1016/S1474-4422(14)70090-0). Open Google Scholar doi.org/10.5771/9783748940920-69
  15. Farrer, L.A./Cupples, L. A. / Haines, J. L. / Hyman, B. / Kukull, W. A. /Mayeux, R. / Myers, R. H. / Pericak-Vance, M. A. / Risch, N. / van Duijn, C. M.: Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease, A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium, JAMA 1997;278(16):1349–1356 (https://doi.org/10.1001/jama.1997.03550160069041). Open Google Scholar doi.org/10.5771/9783748940920-69
  16. Folstein, M. F. / Folstein, S.E. / McHugh, P. R.: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician, J Psychiatr Res 1975;12(3):189–198 (https://doi.org/10.1016/0022-3956(75)90026-6). Open Google Scholar doi.org/10.5771/9783748940920-69
  17. Grant, W. B.: Trends in diet and Alzheimer's disease during the nutrition transition in Japan and developing countries, J Alzheimers Dis 2014;38(3):611–620 (https://doi.org/10.3233/JAD-130719). Open Google Scholar doi.org/10.5771/9783748940920-69
  18. Greenblatt, C.: World Health Organization. Dementia; Available from: https://www.who.int/news-room/fact-sheets/detail/dementia (28 September 2021). Open Google Scholar doi.org/10.5771/9783748940920-69
  19. Hardy, J. / Allsop, D.: Amyloid deposition as the central event in the aetiology of Alzheimer's disease, Trends Pharmacol Sci 1991;12(10):383–388 (https://doi.org/10.1016/0165-6147(91)90609-v). Open Google Scholar doi.org/10.5771/9783748940920-69
  20. Hardy J. A. / Higgins, G. A.: Alzheimer's disease: the amyloid cascade hypothesis, Science 1992;256(5054):184–185 (https://doi.org/10.1126/science.1566067). Open Google Scholar doi.org/10.5771/9783748940920-69
  21. Jack, C. R. / Albert, M. S. / Knopman, D. S. / McKhann, G. M. / Sperling, R. A. / Carrillo, M. C. / Thies, B. / Phelps, C.H.: Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease, Alzheimers Dement 2011;7(3):257–262 (https://doi.org/10.1016/j.jalz.2011.03.004). Open Google Scholar doi.org/10.5771/9783748940920-69
  22. Jack, C.R. / Bennett, D. A. / Blennow, K. / Carrillo, M. C. / Dunn, B. / Haeberlein S. B. / Holtzman, D. M. / Jagust, W. / Jessen, F. / Karlawish, J. / Liu, E. / Molinuevo, J. L. / Montine, T. / Phelps, C. / Rankin, K. P. / Rowe, C. C. / Scheltens, P. / Siemers, E. / Snyder, H. M. / Sperling, R.: NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease, Alzheimers Dement 2018;14(4):535–562 (https://doi.org/10.1016/j.jalz.2018.02.018). Open Google Scholar doi.org/10.5771/9783748940920-69
  23. Jarrett, J. T. / Berger, E. P. / Lansbury, P. T.: The C-terminus of the beta protein is critical in amyloidogenesis, Ann N Y Acad Sci 1993;695:144–148 (https://doi.org/10.1111/j.1749-6632.1993.tb23043.x). Open Google Scholar doi.org/10.5771/9783748940920-69
  24. Kivipelto M. / Solomon, A. / Ahtiluoto, S. / Ngandu, T. / Lehtisalo, J. / Antikainen, R. / Bäckman, L. / Hänninen, T. / Jula, A. / Laatikainen, T. / Lindström, J. / Mangialasche, F. / Nissinen, A. / Paajanen, T. / Pajala, S. / Peltonen, M. / Rauramaa, R. / Stigsdotter-Neely, A. / Strandberg, T. / Tuomilehto, J. / Soininen, H.: The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER): Study design and progress, Alzheimers Dement 2013;9(6):657–665 (https://doi.org/10.1016/j.jalz.2012.09.012). Open Google Scholar doi.org/10.5771/9783748940920-69
  25. Klunk, W.E. / Engler, H. / Nordberg, A. / Wang, Y. / Blomqvist, G. / Holt, D. P. / Bergström, M. / Savitcheva, I, / Huang, G. / Estrada, S. / Ausén, B. / Debnath, M. L. / Barletta, J. / Price, J. C. / Sandell, J. / Lopresti, B. J. / Wall, A. / Koivisto, P. / Antoni, G. / Mathis, C. A. / Långström, B.: Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B, Ann Neurol 2004;55(3):306–319 (https://doi.org/10.1002/ana.20009). Open Google Scholar doi.org/10.5771/9783748940920-69
  26. Lacor, P. N. / Buniel, M. C. / Furlow, P. W. / Clemente, A. S. / Velasco, P. T. / Wood, M. / Viola, K. L. / Klein, W. L.: Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease, J Neurosci 2007;27(4):796–807 (https://doi.org/10.1523/JNEUROSCI.3501-06.2007). Open Google Scholar doi.org/10.5771/9783748940920-69
  27. Letenneur, L. / Launer, L. J. / Andersen, K. / Dewey, M. E. / Ott, A. / Copeland, J. R. / Dartigues, J. F. / Kragh-Sorensen, P. / Baldereschi, M. / Brayne, C. / Lobo, A. / Martinez-Lage, J. M. / Stijnen, T. / Hofman, A.: Education and the risk for Alzheimer's disease: sex makes a difference. EURODEM pooled analyses. EURODEM Incidence Research Group, Am J Epidemiol 2000;151(11):1064–1071 (https://doi.org/10.1093/oxfordjournals.aje.a010149). Open Google Scholar doi.org/10.5771/9783748940920-69
  28. Lipton, S. A.: Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation, Curr Drug Targets 2007;8(5):621–632 (https://doi.org/10.2174/138945007780618472). Open Google Scholar doi.org/10.5771/9783748940920-69
  29. Lobo, A. / Launer, L. J. / Fratiglioni, L. / Andersen, K. / Di Carlo, A. / Breteler, M. M. / Copeland, J. R. / Dartigues, J. F. / Jagger, C. / Martinez-Lage, J. / Soininen, H. / Hofman, A.: Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts, Neurologic Diseases in the Elderly Research Group, Neurology 2000;54(11 Suppl 5):S4–9. Open Google Scholar doi.org/10.5771/9783748940920-69
  30. Löwe, L. C. / Gaser, C. / Franke, K.: The Effect of the APOE Genotype on Individual BrainAGE in Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease, PLoS One 2016;11(7):e0157514 (https://doi.org/10.1371/journal.pone.0157514). Open Google Scholar doi.org/10.5771/9783748940920-69
  31. Lyketsos, C. G. / Steinberg, M. / Tschanz, J. T. / Norton, M. C. / Steffens, D. C. / Breitner, J. C.: Mental and behavioral disturbances in dementia: findings from the Cache County Study on Memory in Aging, Am J Psychiatry 2000;157(5):708–714 (https://doi.org/10.1176/appi.ajp.157.5.708). Open Google Scholar doi.org/10.5771/9783748940920-69
  32. Martinoli, M. G. / Trojanowski, J. Q. / Schmidt, M. L. / Arnold, S. E. / Fujiwara, T. M. / Lee, V. M. / Hurtig, H. / Julien, J. P. / Clark, C.: Association of apolipoprotein epsilon 4 allele and neuropathologic findings in patients with dementia, Acta Neuropathol 1995;90(3):239–243 (https://doi.org/10.1007/BF00296506). Open Google Scholar doi.org/10.5771/9783748940920-69
  33. McKhann, G. M. / Knopman, D. S. / Chertkow, H. / Hyman, B. T. / Jack, C. R. / Kawas, C. H. / Klunk, W. E. / Koroshetz, W. J. / Manly, J. J. / Mayeux, R. / Mohs, R. C. / Morris, J. C. / Rossor, M. N. / Scheltens, P. / Carrillo, M. C. / Thies, B. / Weintraub, S. / Phelps, C. H.: The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease, Alzheimers Dement 2011;7(3):263–269 (https://doi.org/10.1016/j.jalz.2011.03.005). Open Google Scholar doi.org/10.5771/9783748940920-69
  34. Mercy, L. / Hodges, J. R. / Dawson, K. / Barker, R. A. / Brayne, C.: Incidence of early-onset dementias in Cambridgeshire, United Kingdom, Neurology 2008;71(19):1496–1499 (https://doi.org/10.1212/01.wnl.0000334277.16896.fa). Open Google Scholar doi.org/10.5771/9783748940920-69
  35. Meyer, P.-F. / McSweeney, M. / Gonneaud, J. / Villeneuve, S.: AD molecular: PET amyloid imaging across the Alzheimer's disease spectrum: From disease mechanisms to prevention, Prog Mol Biol Transl Sci 2019;165:63–106 (https://doi.org/10.1016/bs.pmbts.2019.05.001). Open Google Scholar doi.org/10.5771/9783748940920-69
  36. Nabers, A. / Ollesch, J. / Schartner, J. / Kötting, C. / Genius, J. / Haußmann, U. / Klafki, H. / Wiltfang, J. / Gerwert, K.: An infrared sensor analysing label-free the secondary structure of the Abeta peptide in presence of complex fluids, J Biophotonics 2016;9(3):224–234 (https://doi.org/10.1002/jbio.201400145). Open Google Scholar doi.org/10.5771/9783748940920-69
  37. Nabers, A. / Ollesch, J. / Schartner, J. / Kötting, C. / Genius, J. / Hafermann, H. / Klafki, H. / Gerwert, K. / Wiltfang, J.: Amyloid-β-Secondary Structure Distribution in Cerebrospinal Fluid and Blood Measured by an Immuno-Infrared-Sensor: A Biomarker Candidate for Alzheimer's Disease, Anal Chem 2016;88(5):2755–2762 (https://doi.org/10.1021/acs.analchem.5b04286). Open Google Scholar doi.org/10.5771/9783748940920-69
  38. Nabers, A. / Perna, L. / Lange, J. / Mons, U. / Schartner, J. / Güldenhaupt, J. / Saum, K.-U. / Janelidze, S. / Holleczek, B. / Rujescu, D. / Hansson, O. / Gerwert, K. / Brenner, H.: Amyloid blood biomarker detects Alzheimer's disease, EMBO Mol Med 2018;10(5): e8763 (https://doi.org/10.15252/emmm.201708763). Open Google Scholar doi.org/10.5771/9783748940920-69
  39. Nandi, A. / Counts, N. / Chen, S. / Seligman, B. / Tortorice, D. / Vigo, D. / Bloom, D. E.: Global and regional projections of the economic burden of Alzheimer's disease and related dementias from 2019 to 2050: A value of statistical life approach, EClinicalMedicine 2022;51:101580 (https://doi.org/10.1016/j.eclinm.2022.101580). Open Google Scholar doi.org/10.5771/9783748940920-69
  40. Nasreddine, Z. S. / Phillips, N. A. / Bédirian, V. / Charbonneau, S. / Whitehead, V. / Collin, I. / Cummings, J. L. / Chertkow, H.: The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment, J Am Geriatr Soc 2005;53(4):695–699 (https://doi.org/10.1111/j.1532-5415.2005.53221.x). Open Google Scholar doi.org/10.5771/9783748940920-69
  41. Peters, K. R. / Rockwood, K. / Black, S. E. / Bouchard, R. / Gauthier, S. / Hogan, D. / Kertesz, A. / Loy-English, I. / Beattie, B. L. / Sadovnick, A. D. / Feldman, H. H.: Characterizing neuropsychiatric symptoms in subjects referred to dementia clinics. Neurology 2006;66(4):523–528 (https://doi.org/10.1212/01.wnl.0000198255.84842.06). Open Google Scholar doi.org/10.5771/9783748940920-69
  42. Prince, M. / Ali, G.-C. / Guerchet, M. / Prina, A. M. / Albanese, E. / Wu, Y.-T.: Recent global trends in the prevalence and incidence of dementia, and survival with dementia, Alzheimers Res Ther. 2016;8(1):23 (https://doi.org/10.1186/s13195-016-0188-8). Open Google Scholar doi.org/10.5771/9783748940920-69
  43. Scarmeas, N. / Stern, Y. / Tang, M.-X. / Mayeux, R. / Luchsinger, J. A.: Mediterranean diet and risk for Alzheimer's disease, Ann Neurol 2006;59(6):912–921 (https://doi.org/10.1002/ana.20854). Open Google Scholar doi.org/10.5771/9783748940920-69
  44. Selkoe, D. J.: The molecular pathology of Alzheimer's disease, Neuron 1991;6(4):487–498 (https://doi.org/10.1016/0896-6273(91)90052-2). Open Google Scholar doi.org/10.5771/9783748940920-69
  45. Sevigny, J. / Chiao, P. / Bussière, T. / Weinreb, P. H. / Williams, L. / Maier, M. / Dunstan, R. / Salloway, S. / Chen, T. / Ling, Y / O'Gorman, J. / Qian, F. / Arastu, M. / Li, M. / Chollate, S. / Brennan, M. S. / Quintero-Monzon, O. / Scannevin, R. H. / Arnold, H. M. / Engber, T. / Rhodes, K. / Ferrero, J. / Hang, Y. / Mikulskis, A. / Grimm, J. / Hock, C. / Nitsch, R. M. / Sandrock, A.: The antibody aducanumab reduces Aβ plaques in Alzheimer's disease, Nature 2016;537(7618):50–56 (https://doi.org/10.1038/nature19323). Open Google Scholar doi.org/10.5771/9783748940920-69
  46. Sims, J. R. / Zimmer, J. A. / Evans, C. D. / Lu, M. / Ardayfio, P. / Sparks, J. / Wessels, A. M. / Shcherbinin, S. / Wang, H. / Monkul, Nery E. S. / Collins, E. C. / Solomon, P. / Salloway, S. / Apostolova, L. G. / Hansson, O. / Ritchie, C. / Brooks, D. A. / Mintun, M. / Skovronsky, D. M.: Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial, JAMA 2023;330(6):512–527 (https://doi.org/10.1001/jama.2023.13239). Open Google Scholar doi.org/10.5771/9783748940920-69
  47. Sperling, R. A. / Aisen, P. S. / Beckett, L. A. / Bennett, D. A. / Craft, S. / Fagan, A. M. / Iwatsubo, T. / Jack, C. R. / Kaye, J. / Montine, T. J. / Park, D. C. / Reiman, E. M. / Rowe, C. C. / Siemers, E. / Stern, Y. / Yaffe, K. / Carrillo, M. C. / Thies, B. / Morrison-Bogorad, M. / Wagster, M. V. / Phelps, C. H.: Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011;7(3):280–292 (https://doi.org/10.1016/j.jalz.2011.03.003). Open Google Scholar doi.org/10.5771/9783748940920-69
  48. Stocker, H. / Nabers, A. / Perna, L. / Möllers, T. / Rujescu, D. / Hartmann, A. / Holleczek, B. / Schöttker, B. / Gerwert, K. / Brenner, H.: Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors, Alzheimers Dement 2020;16(2):283–291 (https://doi.org/10.1016/j.jalz.2019.08.189). Open Google Scholar doi.org/10.5771/9783748940920-69
  49. Stocker, H. / Perna, L. / Weigl, K. / Möllers, T. / Schöttker, B. / Thomsen, H. / Holleczek, B. / Rujescu, D. / Brenner, H.: Prediction of clinical diagnosis of Alzheimer's disease, vascular, mixed, and all-cause dementia by a polygenic risk score and APOE status in a community-based cohort prospectively followed over 17 years, Mol Psychiatry 2021;26(10):5812–5822 (https://doi.org/10.1038/s41380-020-0764-y). Open Google Scholar doi.org/10.5771/9783748940920-69
  50. Stockmann, J. / Verberk, I. M. W. / Timmesfeld, N. / Denz, R. / Budde, B. / Lange-Leifhelm, J. / Scheltens, P. / van der Flier, W. M. / Nabers, A. / Teunissen, C. E. / Gerwert, K.: Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline, Alzheimers Res Ther. 2020;12(1):169 (https://doi.org/10.1186/s13195-020-00738-8). Open Google Scholar doi.org/10.5771/9783748940920-69
  51. Strittmatter, W. J. / Saunders, A. M. / Schmechel, D. / Pericak-Vance, M. / Enghild, J. / Salvesen, G. S. / Roses, A. D.: Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease, Proc Natl Acad Sci U S A 1993;90(5):1977–1981 (https://doi.org/10.1073/pnas.90.5.1977). Open Google Scholar doi.org/10.5771/9783748940920-69
  52. Swanson, C. J. / Zhang, Y. / Dhadda S. / Wang, J. / Kaplow, J. / Lai, R. Y. K. / Lannfelt, L. / Bradley, H. / Rabe, M. / Koyama, A. / Reyderman, L. / Berry, D. A. / Berry, S. / Gordon, R. / Kramer, L. D. / Cummings, J. L.: A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody, Alzheimer's research & therapy 2021;13(1):80 (https://doi.org/10.1186/s13195-021-00813-8). Open Google Scholar doi.org/10.5771/9783748940920-69
  53. Tabet, N.: Acetylcholinesterase inhibitors for Alzheimer's disease: anti-inflammatories in acetylcholine clothing!, Age Ageing 2006;35(4):336–338 (https://doi.org/10.1093/ageing/afl027). Open Google Scholar doi.org/10.5771/9783748940920-69
  54. van Cauwenberghe, C. / van Broeckhoven, C. / Sleegers, K.: The genetic landscape of Alzheimer disease: clinical implications and perspectives, Genet Med 2016;18(5):421–430 (https://doi.org/10.1038/gim.2015.117). Open Google Scholar doi.org/10.5771/9783748940920-69
  55. Villemagne, V. L. / Burnham, S. / Bourgeat, P. / Brown, B. / Ellis, K. A. / Salvado, O. / Szoeke, C. / Macaulay, S. L. / Martins, R. / Maruff, P. / Ames, D. / Rowe, C. C. / Masters, C. L.: Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study, Lancet Neurol 2013;12(4):357–367 (https://doi.org/10.1016/S1474-4422(13)70044-9). Open Google Scholar doi.org/10.5771/9783748940920-69
  56. Wang, Z. / Dong, B. / Zeng, G. / Li, J. / Wang, W. / Wang, B. / Yuan, Q.: Is there an association between mild cognitive impairment and dietary pattern in Chinese elderly? Results from a cross-sectional population study, BMC Public Health 2010;10:595 (https://doi.org/10.1186/1471-2458-10-595). Open Google Scholar doi.org/10.5771/9783748940920-69
  57. Wimo, A. / Guerchet, M. / Ali, G.-C. / Wu, Y.-T. / Prina, A. M. / Winblad, B. / Jönsson, L. / Liu, Z. / Prince, M.: The worldwide costs of dementia 2015 and comparisons with 2010, Alzheimers Dement 2017;13(1):1–7 (https://doi.org/10.1016/j.jalz.2016.07.150). Open Google Scholar doi.org/10.5771/9783748940920-69

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